The Xplorer can be configured as multiple fermentor (for bacteria and yeast culture) or as multiple bio-reactor (for cells culture) and can be fitted with 4 or 8 stirred glass vessels.
Each vessel has a minimum working volume of about 30 ml to minimise media consumption and fully independent control for temperature, pH and agitation. To handle very small working volumes, Xplorer can be fitted with microsampling systems and be easily integrated with analytical instrumentation, such as HPLC, FTIR or mass spectroscopy to collect critical process data.
When configured for cell applications Xplorer can also be integrated with a four gas mixing system (Air, O2, CO2 and N2).
Xplorer can handle batch, fed batch and continuous processes and work as stand-alone system or be controlled by a remote PC, thanks to a powerful dedicated software with an easy- to-use graphical interface.
Xplorer can handle batch, fed batch and continuous processes and controlled by a PC, thanks to a powerful dedicated software with an easy- to-use graphical interface.
BASE UNIT
• Compact, easy to clean 316L stainless steel unit
• Unit contains all electronics and communication interfaces
• Peristaltic pumps for various additions are neatly attached to the sides of the unit, out of the way
• Rotameters for regulating the air flow rate are also fixed onto the unit
• Typical 4-reactor workstation, dimensions: 40cm (W) x 25cm (H) x 25cm (D)
• Two reactor sizes:
- 1. 280ml (60ml minimum working) 60mm dia x 118mm high
2. 500ml (95ml minimum working), 75mm dia x 118mm high
VESSELS
Vessels consist of borosilicate glass and are fitted with 316L stainless steel head plates.
• Two vessel sizes: maximum working volume 280ml and 500ml; minimum volume 60ml ad 95ml.
• All vessels containing media components and fitted with probes are removable from the base unit for sterilisation in an autoclave
• The head plate has been designed with the following ports and openings:
- - pH electrode port
- Dissolved oxygen sensor probe
- 2 x pH feeds
- 2 x liquid feeds (or spare)
- 1 x large spare (e.g. sampling)
- 2 x small spare
- 1 x condenser
- 1 x temperature
DIFFERENT SIZE VESSELS CAN BE USED AT THE SAME TIME
AGITATION SYSTEM
• Each vessel has a magnetically driven Rushton turbine or other low shear type stirrer. The excellent magnetic coupling means the stirrer and drive magnets remain coupled at high speeds in viscous solutions.
• As the Xplorer uses magnetic coupling there is no contamination hazard associated with a shaft rotating through the lid.
• The Stirrers and baffles have been precisely designed to allow easy scale up of processes.
• The agitation is controlled through the software and can be cascaded linked to DO level control.
• Moreover stirrer speed can be fine tuned to bacterial or animal cell culture requirements.
GASSING SYSTEM
• Xplorer can be integrated with a four gas mixing system (air, N2, O2 and CO2), allowing blended gas addition in each reactor for precise control of DO and pH.
• Feedback from the pH probe can be used to control CO2 addition.
• Feedback from the Dissolved Oxygen probe can be used to control O2 addition.
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