The Xpert is an integrated and flexible benchtop multiple bioreactor, designed to match the needs of bioprocess screening and optimisation on a traditional 1000-2000 ml working volume scale.

Xpert can be configured for bacteria, yeast and cell culture applications and set up with a choice of 1, 2 or 4 jacketed and stirred glass vessels, fitted with 316L stainless steel lid and probes as well as specifically designed impellers.

As standard, each vessel comes with its own independent control for temperature, pH, DO and stirring. On request, vessels can be also equipped for on line process data measurement (for instance calorimetric or turbidity measurement), and can be fitted with foam detection probes or specific harvesting and feeding systems.

When configured for cells applications Xpert can house a built-in four gas mixing system (Air, O2, CO2 and N2), with calibrated nozzles and accurate flow rate control.

Great care has been taken in the design details so that routine handling operations such as connecting and disconnecting of probes, cleaning, autoclaving – are easy, reliable and fast.

Xpert can handle batch, fed batch and continuous processes and work as stand-alone system or be controlled by a remote PC, thanks to a powerful dedicated software and a state-of the art graphical interface. Bio Iso software let you keep under control multiple process data at a glance and allows to fine tune process parameters, setup points and alarms, as well as configure, save, load and edit experiment profiles or log experiment data.

Although Xpert is a very advanced system in terms of integration, controls and performance it has a very small footprint (960mm width, 505mm depth) and is delivered as fully turnkey system.

BASE UNIT

Compact, easy to clean 316L stainless steel unit

Unit contains all electronics and communication interfaces

Peristaltic pumps for various additions areneatly attached to the sides of the unit, out ofthe way

Rotameters for regulating the air flow rate are also fixed onto the unit

Typical 4-reactor dimensions: 900cm (W) x 60cm (H) x 50cm (D)

VESSELS

Vessels consist of borosilicate glass and are fitted with 316L stainless steel head plates

Three vessel sizes maximum working range of 500, 1000 and 2000ml, minimum >200ml

5 litre vessels are available

All vessels containing media components and fitted with probes are removable from

The head plate has been designed with the following ports and openings:

- Stirrer motor shaft (central port)
- pH electrode port (12mm)
- Dissolved oxygen sensor port (12mm)
- Inlet gas port – with sparger (6mm)
- Outlet gas port – with exhaust gas condenser (9mm)
- Thermowell for temperature sensor (6mm)
- Spare port (6mm)
- Heater (7mm)
- Sample port (6mm)
- Inoculant port (12mm)
- Acid, base, anti-foam (12mm)

DIFFERENT SIZE VESSELS CAN BE USED AT THE SAME TIME

AGITATION SYSTEM

Each vessel has a Rushton turbine or other client selected agitator type.

The stirrer and baffles have been precisely designed to allow easy scale up of processes.

Agitator seal is a mechanical type for normal bacteria applications and optionally, magnetically coupled seal for cell culture applications.

The agitation is controlled through the software and can be cascaded linked to DO level control. Moreover, stirrer speed can be fine tuned to bacterial or animal cell culture requirements.

GASSING SYSTEM

Xpert can be integrated with a four gas mixing system (air, N2, O2 and CO2), allowing blended gas addition in each reactor for precise control of DO and pH.

Feedback from the pH probe can be used to control CO2 addition.

Feedback from the Dissolved Oxygen probe can be used to control O2 addition.

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